Fecha/hora: 12/05/2024 14:04:57

Biblioteca(s): 	INIA Las Brujas.	
Fecha corriente: 	20/02/2024	
Fecha de la última actualización: 	20/02/2024	
Autoria: 	ROMANIUK, E.; VERA, B.; PERAZA, P.; CIAPPESONI, G.; DAMIÁN, J.P.; VAN LIER, E.	
Afiliación: 	ESTEFANÍA ROMANIUK, Dpto Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Avda. Garzón 780, Montevideo 12900, Uruguay; Estación Experimental Facultad de Agronomía Salto, Ruta 31, km 21, Salto 50000, Uruguay; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO PERAZA DOS SANTOS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN PABLO DAMIÁN, Dpto de Biociencias Veterinarias, Facultad de Veterinaria, Universidad de la República, Ruta 8, km 18, Montevideo 13000, Uruguay; Núcleo de Bienestar Animal, Facultad de Veterinaria, Universidad de la República, Ruta 8, km 18, Montevideo 13000, Uruguay; ELIZE VAN LIER, Dpto Producción Animal y Pasturas, Facultad de Agronomía, Universidad de la República, Avda. Garzón 780, Montevideo 12900, Uruguay; Estación Experimental Facultad de Agronomía Salto, Ruta 31, km 21, Salto 50000, Uruguay.	
Título: 	Identification of candidate genes and pathways linked to the temperament trait in sheep.	
Año de publicación: 	2024	
Fuente/Imprenta: 	Genes. 2024; 15(2):229. https://doi.org/10.3390/genes15020229  -- OPEN ACCESS.	
ISSN: 	eISSN 2073-4425	
DOI: 	10.3390/genes15020229	
Idioma: 	Inglés	
Notas: 	Article history: Submission received: 4 December 2023; Revised: 5 January 2024;  Accepted: 10 January 2024; Published: 11 February 2024. -- Academic Editor: Emilia Bagnicka. -- Funding: This research was funded by the Comisión Sectorial de Investigación Científica (CSIC, Universidad de la República), which approved the project CSIC_I+D_2018_287; the SMARTER project funded by the European Union Horizon 2020 program (agreement no. 772787); the projects INIA CL 40 (resistance to parasites) and CL 38 (RUMIAR); and to the Comité Académico de Posgrados for the scholarship master?s degree 2020 (POS_NAC_2019_1_157979), Universidad de la República. -- Institutional Review Board Statement: The animal study protocol was approved by the Honorary Commission for Animal Experimentation (Comisión Honoraria de Experimentación Animal, CHEA, protocols N° 021130-006307-11 and 020300-000653-18-ID, CHEA 701), Universidad de la República. -- This article belongs to the Section Animal Genetics and Genomics (https://www.mdpi.com/journal/genes/sections/Animal_Genetics_Genomics ) -- Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).	
Contenido: 	ABSTRACT.- Temperament can be defined as the emotional variability among animals of the same species in response to the same stimulus, grouping animals by their reactivity as nervous, intermediate, or calm. Our goal was to identify genomic regions with the temperament phenotype measured by the Isolation Box Test (IBT) by single-step genome-wide association studies (ssGWAS). The database consisted of 4317 animals with temperament records, and 1697 genotyped animals with 38,268 effective Single Nucleotide Polymorphism (SNP) after quality control. We identified three genomic regions that explained the greatest percentage of the genetic variance, resulting in 25 SNP associated with candidate genes on chromosomes 6, 10, and 21. A total of nine candidate genes are reported for the temperament trait, which is: PYGM, SYVN1, CAPN1, FADS1, SYT7, GRID2, GPRIN3, EEF1A1 and FRY, linked to the energetic activity of the organism, synaptic transmission, meat tenderness, and calcium associated activities. This is the first study to identify these genetic variants associated with temperament in sheep, which could be used as molecular markers in future behavioral research. © 2024 by the authors.	
Palabras-Clave: 	CAPN1; GRID2; Ovis aries; PYMG; SISTEMA GANADERO EXTENSIVO - INIA; SsGWAS; SYT7.	
Categoría del tema: 	L01 Ganadería	
URL: 	https://www.mdpi.com/2073-4425/15/2/229/pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (103812-1) - PXI - AP - DD - GENES/2024 -  -  - DIS